It is the main cause of death related to poisoning in multiple countries, and more importantly, it may lead to fetal poisoning in over half of the global population ( 2). Brain injury caused by CO poisoning may be different in adults and children.Ĭarbon monoxide (CO), which is tasteless, colorless, and odorless, is absorbed into the human body across the lining of the lungs ( 1). In addition, the correlational analysis of CO-poisoned patients revealed a statistical association between the GluCEST% and the MMSE in the thalamus and the genu of the corpus callosum.Ĭonclusion: The GluCEST technique is superior to routine MRI in that it can identify the cerebral biochemical changes sooner after acute CO poisoning, which is significant for our understanding of the role of neurotransmitters in the pathological basis of this disease. In the subgroup analysis for age, adult patients had higher GluCEST% in the basal ganglia, the thalamus, the occipital lobe, the cingulate gyrus, and the cuneus compared to healthy adults ( p < 0.05). Results: As compared to the healthy control, the CO group led to significantly increasing GluCEST% in the basal ganglia, the occipital lobe, the genu of the corpus callosum, the cingulate gyrus, and the cuneus ( p < 0.05). Moreover, an age-stratified subgroup analysis was devised, and a correlational analysis was performed for GluCEST% in each ROI, including the time in coma, Simple Mini-Mental State Examination Scale (MMSE) score, Hamilton Anxiety Scale score, and blood COHb%. Between-group comparisons were conducted for GluCEST% in regions of interest (ROI), including the basal ganglia, the thalamus, the frontal lobe, the occipital lobe, the genu of corpus callosum, the cingulate gyrus, and the cuneus. Methods: The routine MRI and functional MRI scans of two cohorts of subjects (CO group, n = 29 Control group, n = 21) were performed. 3Department of Radiology, Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Shenzhen, ChinaĪims: This study adopted the Glutamate Chemical Exchange Saturation Transfer (GluCEST) imaging technique to quantitatively analyze cranial glutamate and discussed the effectiveness of GluCEST values in identifying the pathogenesis of encephalopathy after CO poisoning.2Department of Radiology, Huizhou City Center People's Hospital, Huizhou, China.1Department of Radiology, The Second Affiliated Hospital, Medical College of Shantou University, Shantou, China.Hongyi Zheng 1, Wenbin Zheng 1 *, Hongkun Liu 2, Gengbiao Zhang 1, Weijia Li 1, Jiayan Zhuang 1 and Yuelin Guo 3
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